Rapid Construction of Tricyclic Furanobenzodihydropyrans by Asymmetric Tandem Reaction
Yulong Zhang, Jingxiang Duan, Yuqiao Zhou, Xiaoyi Li, Weijun Yao, Zhen Wang
Abstract
A process based on the organocatalyzed Mannich/cycloketalization/transesterification tandem reaction of 1-(2-hydroxyaryl)-1,3-diketones and β,γ-alkynyl α-imino esters has been developed, delivering a variety of tricyclic furanobenzodihydropyrans with excellent results (up to 99% yield, 99% ee, and >19:1 dr).
Topics & Concepts
TricyclicTandemYield (engineering)TransesterificationChemistryMannich reactionOrganic chemistryCombinatorial chemistryCatalysisMaterials scienceComposite materialMetallurgySynthesis of Indole DerivativesSynthetic Organic Chemistry MethodsAsymmetric Synthesis and Catalysis