Lung-on-chip microdevices to foster pulmonary drug discovery
Yashi Sisodia, Komal Shah, Adil Ali Sayyed, Meenakshi Jain, Syed Ansar Ali, Piyush Gondaliya, Kiran Kalia, Rakesh Kumar Tekade
Abstract
miniaturized bionic simulation of the lung holds great potential in the quest for a successful therapeutic intervention. This review discusses the emerging roles of lung-on-chip microfluidic simulator devices in fostering translational pulmonary drug discovery and personalized medicine. This review also explicates how the lung-on-chip model emulates the breathing patterns, elasticity, and vascularization of lungs in creating a 3D pulmonary microenvironment.
Topics & Concepts
LungMicrofluidic chipDrug discoveryPersonalized medicineMedicineOrgan-on-a-chipHuman lungDrugDrug developmentIn vivoComputer scienceComputational biologyIntensive care medicineNanotechnologyMicrofluidicsBioinformaticsPharmacologyBiologyInternal medicineMaterials scienceBiotechnology3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationInhalation and Respiratory Drug Delivery