Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice
Guadalupe Rodríguez, Mesut Eren, Isabel Haupfear, Kirsten L. Viola, Erika N. Cline, Toshio Miyata, William L. Klein, Douglas E. Vaughan, Hongxin Dong
Topics & Concepts
NeuropathologyPlasminogen activator inhibitor-1DementiaPlasminogen activatorMedicineCognitive declineInternal medicineEndocrinologyNeurosciencePsychologyDiseaseProtease and Inhibitor MechanismsAlzheimer's disease research and treatmentsBarrier Structure and Function Studies