Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections
Yishun Guo, Siyuan Qian, Lu Wang, Jiahong Zeng, Renjie Miao, Yongchun Meng, Yingying Jin, Hao Chen, Bailiang Wang
Abstract
Corneal infection is an important cause of corneal damage and vision loss. In this work, polyhydroxy antibiotics were grafted onto polymer brush-modified contact lenses through dynamic chemical bonds between polyphenolic hydroxyls and phenylboronic acid. Both in vitro and in vivo antibacterial tests demonstrated great promise in the prevention of bacterial keratitis, which could be attributed to the enhanced retention time and drug bioavailability.
Topics & Concepts
Materials scienceAntibioticsPolymerOphthalmologyMedicineMicrobiologyComposite materialBiologyOcular Surface and Contact LensCorneal Surgery and TreatmentsCorneal surgery and disorders