Production of novel pladienolide analogues through native expression of a pathway-specific activator
Thomas Booth, John A. Kalaitzis, Daniel Vuong, Andrew Crombie, Ernest Lacey, Andrew M. Piggott, Barrie Wilkinson
Abstract
Reactivation of quiescent polyketide production in a domesticated lab strain.
Topics & Concepts
Activator (genetics)Expression (computer science)Computational biologyCell biologyChemistryBiologyStereochemistryBiochemistryComputer scienceGeneProgramming languagePlant biochemistry and biosynthesisMicrobial Natural Products and BiosynthesisSynthetic Organic Chemistry Methods