Emerging roles of HOTAIR in human cancer
Chunjue Yuan, Yong Ning, Yunbao Pan
Abstract
Long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is overexpressed in many types of cancers, and substantial evidence has suggested a link between cancers and HOTAIR. In the present study, we reviewed the structure and the corresponding biologic function of HOTAIR to clarify its molecular mechanism in cancer progression. HOTAIR promotes proliferation, invasion, and migration, and inhibits apoptosis in cancer cells. HOTAIR also participates in the pathogenesis and progression of cancer by regulating inflammation and immune signaling. These findings suggested that HOTAIR is a novel biomarker in human cancers.
Topics & Concepts
HOTAIRCancer researchLong non-coding RNABiologyCancerHox geneMechanism (biology)RNAGene expressionGeneGeneticsPhilosophyEpistemologyCancer-related molecular mechanisms researchRNA Research and Splicinginterferon and immune responses