A Series of Deoxyfluorination Reagents Featuring OCF<sub>2</sub> Functional Groups
Shiyu Zhao, Yong Guo, Zhaoben Su, Wei Cao, Cheng‐Ying Wu, Qing‐Yun Chen
Abstract
Research on perfluoroalkyl ether carboxylic acids (PFECAs) as alternatives for perfluoroalkyl substances continues with the goal of protecting the environment. However, very little is known about the utilization of decomposition products of PFECAs. We report herein a new series of deoxyfluorination reagents featuring OCF2 functional groups derived from certain PFECAs. Alkyl fluorides were generated from various alcohols in ≤97% yield by these novel reagents. The mechanistic experiment verified in situ generation of carbonic difluoride (COF2).
Topics & Concepts
ChemistryReagentYield (engineering)DecompositionFunctional groupCombinatorial chemistryEtherAlkylOrganic chemistryMetallurgyMaterials sciencePolymerFluorine in Organic ChemistryPer- and polyfluoroalkyl substances researchInorganic Fluorides and Related Compounds