The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair
Sonia Jimeno, Fernando R. Balestra, Pablo Huertas
Abstract
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance. Thus, the fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues. Among those different tiers of regulation, RNA modifications have just emerged as a promising field.
Topics & Concepts
DNADNA repairBiologyRNACell biologyDNA damageComputational biologyGeneticsDouble strandGeneRNA modifications and cancerRNA Research and SplicingRNA and protein synthesis mechanisms