In Search of Spectroscopic Signatures of Periodontitis: A SERS-Based Magnetomicrofluidic Sensor for Detection of <i>Porphyromonas gingivalis</i> and <i>Aggregatibacter actinomycetemcomitans</i>
Evelin Witkowska, Anna M. Łasica, Krzysztof Niciński, Jan Potempa, Agnieszka Kamińska
Abstract
@AgNPs). Thus, it is possible to magnetically separate investigated bacteria from other components of a specimen using the microfluidic chip. To obtain additional enhancement of the Raman signal, the NPs adsorbed to bacterial cells were magnetically attracted to the Si/Ag SERS platform. Afterward, the SERS spectra could be recorded. Such a time-saving procedure can be very helpful in rapid medical diagnostics and thus in starting the appropriate pharmacological therapy to prevent the development of periodontitis and associated comorbidities, e.g., Alzheimer's disease.
Topics & Concepts
Porphyromonas gingivalisAggregatibacter actinomycetemcomitansPeriodontal pathogenPathogenPeriodontitisRaman spectroscopyMicrobiologyPeriodontal diseaseRaman scatteringSurface-enhanced Raman spectroscopyStreptococcus mutansChronic periodontitisChemistryBiologyMaterials scienceBacteriaMedicineDentistryPhysicsOpticsGeneticsSpectroscopy Techniques in Biomedical and Chemical ResearchOral microbiology and periodontitis researchBiosensors and Analytical Detection