Helminth infections drive heterogeneity in human type 2 and regulatory cells
Karin de Ruiter, Simon P. Jochems, Dicky L. Tahapary, Koen A. Stam, Marion König, Vincent van Unen, Sandra Laban, Thomas Höllt, Moustapha Mbow, Boudewijn P. F. Lelieveldt, Frits Koning, Erliyani Sartono, Johannes W. A. Smit, Taniawati Supali, Maria Yazdanbakhsh
Abstract
B cells were found to be the main IL-10 producers among B cells in Indonesians, a subset that was almost absent in Europeans. A number of the distinct immune profiles were driven by helminths as the profiles reverted after clearance of helminth infections. Moreover, Indonesians with no helminth infections residing in an urban area showed immune profiles that resembled Europeans rather than rural Indonesians, which excludes a major role for ethnicity. Detailed insight into the human type 2 and regulatory networks could provide opportunities to target these cells for more precise interventions.