Thermoresponsive block copolymer brush for temperature-modulated hepatocyte separation
Kenichi Nagase, Naoto Kojima, Mitsuaki Goto, Toshihiro Akaike, Hideko Kanazawa
Abstract
-PNIPAAm brush can separate hepatic cells from contaminant cells by temperature modulation, without affecting cell activity or modifying the cell surface. Thus, the copolymer brush is expected to be a useful separation tool for cell therapy and tissue engineering using hepatocytes.
Topics & Concepts
CopolymerBrushPolymer brushMaterials scienceHepatocytePolymerChemical engineeringBlock (permutation group theory)Polymer chemistryChemistryComposite materialBiochemistryPolymerizationIn vitroMathematicsEngineeringGeometryLiver physiology and pathology3D Printing in Biomedical ResearchRNA Interference and Gene Delivery