Synthesis and preclinical evaluation of a heterodimeric radioligand targeting fibroblast activation protein and integrin-αvβ3
Qingsong Yan, Jiawei Zhong, Yang Liu, Simin Peng, Pengju Feng, Yuhua Zhong, Kongzhen Hu, Kongzhen Hu
Topics & Concepts
Fibroblast activation protein, alphaDOTABiodistributionInternalizationChemistryRadioligandIntegrinLigand (biochemistry)Spect imagingCancer researchImaging agentMolecular biologyIn vitroBiophysicsCellNuclear medicineReceptorCancerIn vivoBiochemistryMedicineChelationBiologyInternal medicineOrganic chemistryBiotechnologyPeptidase Inhibition and AnalysisProtease and Inhibitor MechanismsNeuropeptides and Animal Physiology