The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells
Yung-Chieh Chang, Sree Karani Kondapuram, Tsung-Han Yang, Safiulla Basha Syed, Siao Muk Cheng, Tzu‐Yu Lin, Yi-Chen Lin, Mohane Selvaraj Coumar, Jang‐Yang Chang, Euphemia Leung, Chun Hei Antonio Cheung
Topics & Concepts
MedicineCancerCancer researchSurvivinInhibitor of apoptosisPharmacologyInternal medicineBiologyApoptosisBiochemistryProgrammed cell deathDrug Transport and Resistance MechanismsCancer therapeutics and mechanismsNatural Compounds in Disease Treatment