Role of mitochondria-endoplasmic reticulum coupling in lycopene preventing DEHP-induced hepatotoxicity
Yi Zhao, Jia-Gen Cui, Hao Zhang, Xue‐Nan Li, Muzi Li, Milton Talukder, Jin‐Long Li
Abstract
), but LYC alleviated these alterations. Therefore, LYC prevented DEHP-induced hepatic mitochondrial dynamics and MAM disorder, leading to ER stress. The present study provides novel evidence of mitochondria-ER coupling as a target for LYC that prevents DEHP-induced hepatotoxicity.
Topics & Concepts
Endoplasmic reticulumChemoprotectiveChemistryMitochondrionPharmacologyBiochemistryCell biologyAntioxidantBiologyAntioxidant Activity and Oxidative StressVitamin C and Antioxidants ResearchMitochondrial Function and Pathology