Electrochemical Synthesis of α-Thiocyanated/Methoxylated Ketones Using Enol Acetates
Peng Zhang, Junwei Ma, Xuan Liu, Fei Xue, Yonghong Zhang, Bin Wang, Weiwei Jin, Yu Xia, Chenjiang Liu
Abstract
We have developed the synthesis of α-substituted ketone compounds with enol acetates in an electrochemical way. By using cheap NH 4 SCN and MeOH as the radical sources, a series of valuable α-thiocyanates/methoxy ketones were synthesized under mild electrolysis conditions in acceptable yields with diverse functional group compatibility. Additionally, the scale-up experiment and synthetic transformations reveal potential applications in organic synthesis.
Topics & Concepts
EnolKetoneElectrolysisElectrochemistryChemistryOrganic synthesisCombinatorial chemistryCompatibility (geochemistry)Organic chemistryMaterials scienceCatalysisElectrodePhysical chemistryComposite materialElectrolyteSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods