Synthesis of Fentanyl under Continuous Photoflow Conditions
Felipe C. Braga, Tiago O. Ramos, Timothy J. Brocksom, Kléber T. de Oliveira
Abstract
An advantageous and original synthesis of fentanyl is described. This new approach includes two efficient continuous flow reductive aminations achieved via photoredox catalysis and a final batch acylation. A telescoped protocol for the two photocatalyzed steps is also presented, and overall, this protocol provides improved sustainability, significant efficiency, reduced temperatures and reaction times, and is functional for scaling up this relevant active pharmaceutical ingredient (API).
Topics & Concepts
ChemistryAcylationActive ingredientPhotoredox catalysisCombinatorial chemistryContinuous flowCatalysisFlow chemistryFentanylProtocol (science)Organic chemistryBiochemical engineeringPhotocatalysisPharmacologyAlternative medicineMedicinePathologyEngineeringInnovative Microfluidic and Catalytic Techniques InnovationChemical Reactions and IsotopesRadical Photochemical Reactions