One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors
Vahid Ahmadi, Chuanxiong Nie, Ehsan Mohammadifar, Katharina Achazi, Stefanie Wedepohl, Yannic Kerkhoff, Stephan Block, Nikolaus Osterrieder, Rainer Haag
Abstract
A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.
Topics & Concepts
Herpes simplex virusAlkylChemistryGramHeparinPolymerCombinatorial chemistrySulfationStereochemistryVirusOrganic chemistryBiochemistryBiologyVirologyBacteriaGeneticsDendrimers and Hyperbranched PolymersRNA Interference and Gene DeliveryProteoglycans and glycosaminoglycans research