An isotope-dilution LC-MS/MS method for the simultaneous quantification of meropenem and its open-ring metabolite in serum
Sophie Rakete, Carina Schuster, Michael Paal, Michael Vogeser
Topics & Concepts
MeropenemChemistryChromatographyProtein precipitationLiquid chromatography–mass spectrometrySelected reaction monitoringFormic acidMetaboliteTandem mass spectrometryTherapeutic drug monitoringAmmonium formateMass spectrometryPharmacokineticsAntibioticsPharmacologyBiochemistryMedicineAntibiotic resistanceAntibiotics Pharmacokinetics and EfficacyAnalytical Methods in PharmaceuticalsPneumonia and Respiratory Infections