Metal free C-3 chalcogenation (sulfenylation and selenylation) of 4<i>H</i>-pyrido[1,2-<i>a</i>]pyrimidin-4-ones
Prasanjit Ghosh, Gautam Chhetri, Sajal Das
Abstract
]pyrimidin-4-one has been devised to synthesize diversely orchestrated 3-ArS/ArSe derivatives in high yields (up to 95%). This operationally simple reaction proceeds under mild reaction conditions, can be executed in gram scale, and also highlights broad functional group tolerance. Preliminary experimental investigation suggests a radical mechanistic pathway for these transformations.
Topics & Concepts
ChemistryMetalMedicinal chemistryStereochemistryOrganic chemistrySulfur-Based Synthesis TechniquesSynthesis and biological activityPhenothiazines and Benzothiazines Synthesis and Activities