Azole‐Directed Cobalt‐Catalyzed Asymmetric Hydrogenation of Alkenes
Yue Jin, Yashi Zou, Yanhua Hu, Yunxi Han, Zhenfeng Zhang, Wanbin Zhang
Abstract
The azole-directed cobalt-catalyzed asymmetric hydrogenation of alkenes has been developed with high efficiency. With this approach, chiral pyrazole compounds were obtained in quantitative yields and excellent enantioselectivities (up to 99 % ee) under mild conditions, and the hydrogenation was conducted on a gram scale with up to 2000 TON. Several useful applications were demonstrated including the convenient introduction of β-chirality to a drug intermediate containing an azole ring.
Topics & Concepts
AzoleCobaltCatalysisAsymmetric hydrogenationCombinatorial chemistryChirality (physics)ChemistryRing (chemistry)PyrazoleEnantioselective synthesisOrganic chemistryAntifungalDermatologyNambu–Jona-Lasinio modelQuarkPhysicsMedicineQuantum mechanicsChiral symmetry breakingAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisAsymmetric Synthesis and Catalysis