A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice
Dieudonné Buh Kum, Robbert Boudewijns, Ji Ma, Niraj Mishra, Dominique Schols, Johan Neyts, Kai Dallmeier
Abstract
T cells, nor ZIKV neutralizing antibodies are required to confer protection against YFV. The chimeric YF-ZIKprM/E vaccine may thus be considered as a dual vaccine candidate efficiently protecting mice against both the ZIKV and the YFV, and this following a single dose immunization. Our finding may be particularly important in the rational design of vaccination strategies against flaviviruses, in particular in areas where YFV and ZIKV co-circulate.
Topics & Concepts
Yellow feverVirologyZika virusYellow fever vaccineImmunizationVirusFlavivirusBiologyVaccinationOutbreakDengue feverAntibodyImmunologyMosquito-borne diseases and controlMalaria Research and ControlViral Infections and Vectors