Controlled isolation and stabilisation of pure metastable carbamazepine form IV by droplet-confinement <i>via</i> a continuous manufacturing route
Alice Parkes, Ahmad Ziaee, Gavin Walker, Emmet O’Reilly
Abstract
This study outlines a systematic approach to control the polymorphism of carbamazepine (CBZ) and isolate the metastable polymorph CBZ form IV as a function of droplet size using spray drying as a continuous method of manufacture.
Topics & Concepts
CarbamazepineMetastabilityPolymorphism (computer science)Materials scienceChemical engineeringChemistryOrganic chemistryMedicineEngineeringEpilepsyGenotypeBiochemistryGenePsychiatryInhalation and Respiratory Drug DeliveryInnovative Microfluidic and Catalytic Techniques InnovationElectrohydrodynamics and Fluid Dynamics