One‐Pot Synthesis of Hantzsch 1,4‐Dihydropyridines by a Series of Iron Oxide Nanoparticles: Putative Synthetic TRPV6 Calcium Channel Blockers
Mohammad Taqi Jafari‐Chermahini, Hossein Tavakol
Abstract
Abstract Various spinel iron oxide nanoparticles (MFe 2 O4, M: Ca, Co, Cu, Fe, Hg, Mg, Mn, Ni, Sn and Zn) have been prepared using a single step coprecipitation method. Nanoparticles were characterized using XRD, FESEM, FT‐IR and UV‐Vis diffuse‐reflectance spectroscopy. The catalytic activities of the synthesized nanoparticles in Hantzsch reaction have been studied. HgFe 2 O 4 NPs exhibits the highest catalytic activity than others. The structural properties of synthesized 1,4‐dihydropyridine were characterized by mass spectrometry, FT‐IR and 1 H‐ and 13 C‐NMR. Finally, the in silico molecular simulations for screening of blocking ability of synthesized 1,4‐dihydropyridine against various TRPV6 proteins were performed. These studies revealed that examined 1,4‐dihydropyridines are promising TRPV6 calcium channel blockers. As a result, molecular modeling confirmed that synthesized 1,4‐DHPs are docked on the pore region of the examined TRPV6 channels.