Targeted clearance of extracellular Tau using aptamer-armed monocytes alleviates neuroinflammation in mice with Alzheimer’s disease
Yuting Zhuo, Lu Yao, Yan Zhu, Nachuan Wen, Guang-Jing Zou, Hongkun Lu, Xinyu Pei, Yutong Zhang, Qiang Zhang, Xin Wang, Wenjuan Zhang, Qingyang Zhang, Zhimin Wang, Sitao Xie, Chang-Qi Li, Weihong Tan, Liping Qiu
Topics & Concepts
NeuroinflammationExtracellularIntracellularCell biologyPharmacologyChemistryCancer researchBone marrowMonocyteMacrophageHippocampusCentral nervous systemMicrogliaInflammationBlood–brain barrierMedicineViability assayTumor necrosis factor alphaImmunologyNeuroscienceCell therapyNeurotoxicityIn vivoBiologyCellDiseaseGenetically modified mouseToxicityAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research