Cancer-Targeting Applications of Cell-Penetrating Peptides
Liliana Marisol Moreno‐Vargas, Diego Prada‐Gracia
Abstract
Cell-penetrating peptides (CPPs) offer a unique and efficient mechanism for delivering therapeutic agents directly into cancer cells. These peptides can traverse cellular membranes, overcoming one of the critical barriers in drug delivery systems. In this review, we explore recent advancements in the application of CPPs for cancer treatment, focusing on mechanisms, delivery strategies, and clinical potential. The review highlights the use of CPP-drug conjugates, CPP-based vaccines, and their role in targeting and inhibiting tumor growth.
Topics & Concepts
CancerDrug deliveryCell-penetrating peptideMechanism (biology)Cancer cellTargeted drug deliveryCellMedicineDrugCancer researchChemistryComputational biologyPharmacologyNanotechnologyBiologyBiochemistryMaterials scienceInternal medicinePhilosophyEpistemologyRNA Interference and Gene DeliveryAntimicrobial Peptides and ActivitiesImmunotherapy and Immune Responses