Immune infiltration and a ferroptosis-associated gene signature for predicting the prognosis of patients with endometrial cancer
Weijiao Yin, Liao Fuchun, Mengjie Chen, Xiaoqing Qin, Lai Hao, Lin Yuan, Yao Desheng
Abstract
) related to overall survival using LASSO regression analysis. The samples were divided into low- and high-risk subgroups according to the median risk score. Kaplan-Meier survival curves showed that the low-risk group had better OS. ROC curves showed that this signature performed well in predicting OS (1-, 2-, 3-, and 5-year AUCs of 0.676, 0.775, 0.797, and 0.826, respectively). We systematically analyzed the immune infiltrating profile in UCEC samples from TCGA. Overall, our study identified a novel prognostic signature of 8 FRGs that can potentially predict the prognosis of EC.
Topics & Concepts
Infiltration (HVAC)Immune systemEndometrial cancerGeneSignature (topology)MedicineCancerOncologyCancer researchBiologyInternal medicineImmunologyGeneticsMathematicsGeometryThermodynamicsPhysicsFerroptosis and cancer prognosisCancer-related molecular mechanisms researchRNA modifications and cancer