Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
Severin Lechner, Martin Ian P. Malgapo, Christian Grätz, Raphael R. Steimbach, Agnès Baron, Patrick Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K. Pauling, Karl Kramer, Aubry K. Miller, Michael W. Pfaffl, Maurine E. Linder, Bernhard Küster, Guillaume Médard
Topics & Concepts
Histone deacetylaseDrug discoveryHDAC6ChemistryBiochemistryPotencyProteomicsComputational biologyPharmacologyBiologyHistoneIn vitroGeneHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisEpigenetics and DNA Methylation