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Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Severin Lechner, Martin Ian P. Malgapo, Christian Grätz, Raphael R. Steimbach, Agnès Baron, Patrick Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K. Pauling, Karl Kramer, Aubry K. Miller, Michael W. Pfaffl, Maurine E. Linder, Bernhard Küster, Guillaume Médard

2022Nature Chemical Biology112 citationsDOIOpen Access PDF

Topics & Concepts

Histone deacetylaseDrug discoveryHDAC6ChemistryBiochemistryPotencyProteomicsComputational biologyPharmacologyBiologyHistoneIn vitroGeneHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisEpigenetics and DNA Methylation
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target | Litcius