Fe(III)-Catalyzed Decarboxylative C3-Difluoroarylmethylation of Coumarins with α,α-Difluoroarylacetic Acids
Zhiwei Chen, Xiang Bai, Jie Sun, Yicheng Xu
Abstract
A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series of C-3 difluoroarylmethylated coumarins containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.
Topics & Concepts
ChemistryCatalysisOrganic chemistrySimplicityOxidative coupling of methaneCombinatorial chemistryEpistemologyPhilosophyFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods