An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancer
Artem V. Artemov, Svetlana Zhenilo, Daria Kaplun, Alexey Starshin, Alexey Sokolov, Alexander M. Mazur, Justyna Szpotan, Maciej Gawroński, Martyna Modrzejewska, Daniel Gackowski, Egor Prokhortchouk
Abstract
genes that cause the accumulation of 2-hydroxyglutarate - a metabolite that inhibits DNA demethylation by TET enzymes. Unlike the known cases of DNA hypermethylation in cancer, 2-hydroxyglutarate was accumulated in the cells with the wild-type isocitrate dehydrogenases.
Topics & Concepts
BiologyDNA methylationDNA demethylationEpigeneticsCancer researchMethylationGeneDNATranscription factorMolecular biologyGeneticsGene expressionEpigenetics and DNA MethylationCancer, Hypoxia, and MetabolismRNA modifications and cancer