Investigation of Heterochromatin Protein 1 Function in the Malaria Parasite Plasmodium falciparum Using a Conditional Domain Deletion and Swapping Approach
Hai T. N. Bui, Armin Passecker, Nicolas M. B. Brancucci, Till S. Voss
Abstract
Malaria is caused by unicellular Plasmodium species parasites that repeatedly invade and replicate inside red blood cells. Some blood-stage parasites exit the cell cycle and differentiate into gametocytes that are essential for malaria transmission via the mosquito vector.
Topics & Concepts
Plasmodium falciparumParasite hostingMalariaHeterochromatinDomain (mathematical analysis)Heterochromatin protein 1BiologyFunction (biology)Computational biologyPlasmodium (life cycle)VirologyGeneticsComputer scienceImmunologyMathematicsGeneChromosomeWorld Wide WebMathematical analysisMalaria Research and Controlvaccines and immunoinformatics approachesRNA and protein synthesis mechanisms