Engineering Hibiscus‐Like Riboflavin/ZIF‐8 Microsphere Composites to Enhance Transepithelial Corneal Cross‐Linking (Adv. Mater. 21/2022)
Mei Yang, Wenjin Xu, Zhongxing Chen, Ming Chen, Xiaoyu Zhang, Huanhuan He, Yushan Wu, Xueyang Chen, Tianjiao Zhang, Mengdi Yan, Jieyi Bai, Colm McAlinden, Keith M. Meek, Jinjin Yu, Shengnan Ding, Rongrong Gao, Jinhai Huang, Xingtao Zhou
Abstract
Corneal Cross-Linking ln article number 2109865, Rongrong Gao, Jinhai Huang, Xingtao Zhou, and co-workers report novel engineering of hydrangea-like RF@ZIF-8 microsphere composites with outstanding trans-epithelial corneal cross-linking (TE-CXL) efficacy, suggesting a promising nanomedicine strategy. The described use of the metal–organic framework as carrier to transfer hydrophilic negatively charged Riboflavin-5-phosphate (RF) molecules to the hydrophobic corneal epithelium, with excellent TE-CXL efficacy, may open up a new field of CXL.