Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) modulates the proliferation and apoptosis of acute lymphoblastic leukemia cells by sponging miR-486-5p
Jin-Ke Ju, Weina Han, Cai-Ling Shi
Abstract
, PVT1 silencing repressed the tumor growth of SUP-B15 cells and reduced the expression of MAML3. Altogether, silencing of PVT1 inhibited ALL cell growth and induced cell apoptosis through sponging miR-486-5p.
Topics & Concepts
Gene silencingApoptosisJurkat cellsPVT1Cell growthmicroRNADownregulation and upregulationCancer researchTransfectionBiologyCellViability assayMolecular biologyCell biologyCell cultureLong non-coding RNAGeneT cellImmunologyGeneticsImmune systemCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases