Site-selective amination and/or nitrilation<i>via</i>metal-free C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cleavage of benzylic and allylic alcohols
Raghunath Reddy Anugu, John R. Falck
Abstract
Benzylic/allylic alcohols are converted via site-selective C(sp 2 )–C(sp 3 ) cleavage to value-added nitrogenous motifs, viz. , anilines and/or nitriles as well as N-heterocycles, utilizing commercial hydroxylamine- O -sulfonic acid (HOSA) and Et 3 N in an operationally simple, one-pot process.
Topics & Concepts
Allylic rearrangementHydroxylamineAminationChemistryCleavage (geology)Medicinal chemistryOrganic chemistryStereochemistryCatalysisMaterials scienceFracture (geology)Composite materialCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis