Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated trafficking
Stephen Ireland, Haoran Huang, Jianchao Zhang, Jie Li, Yanzhuang Wang
Abstract
H 2 O 2 treatment induces the degradation of Golgi structural proteins in the trans-Golgi, including Arl1, Golgin-97, and Golgin-245, and thereby impairs membrane trafficking. This study revealed the trans-Golgi and trafficking at the trans-Golgi as novel targets of ROS in cells.
Topics & Concepts
Golgi apparatusEndoplasmic reticulumCell biologyBiologyReactive oxygen speciesMitochondrionHydrogen peroxideBiochemistryMitochondrial Function and PathologyCellular transport and secretionEndoplasmic Reticulum Stress and Disease