miR-24-3p promotes colon cancer progression by targeting ING1
Zhiying Gao, Likun Zhou, Shiyu Hua, Huan Wu, Laizhi Luo, Libo Li, Shuping Wang, Yanqing Liu, Zhen Zhou, Xi Chen
Abstract
Activation or upregulation of oncogenes and/or loss of function or downregulation of tumour suppressors are central to the processes involved in the transformation from normal colonic mucosa to malignant tumours. Inhibitor of growth 1 (ING1) has been functionally linked to cell cycle arrest, apoptosis and chromatin remodelling. 1 Deregulated ING1 expression is a crucial event in haematological malignancies and solid tumours, such as breast, 2 lung 3 and colorectal cancer. 4 Despite advances in identifying ING1-controlled cellular functions, ING1 regulation during colon cancer development remains largely unknown.
Topics & Concepts
Colorectal cancerCancer researchCancerBiologyMedicineGeneticsMicroRNA in disease regulationCircular RNAs in diseasesCancer-related molecular mechanisms research