Carvacrol-loaded liposome suspension: optimization, characterization and incorporation into poly(vinyl alcohol) films
Adassa Gama Tavares, Johana Andrade, Rafael Resende Assis Silva, Clara Suprani Marques, José Osvaldo Ramos Silva, Maria Cristina Dantas Vanetti, Nathália Ramos de Melo, Nilda de Fátima Ferreira Soares
Abstract
of carvacrol. Carvacrol reduced the polydispersity index and increased the zeta potential and the thermal stability of liposomes. Fourier-transform infrared spectroscopy indicated that the interaction of carvacrol with liposomes occurred probably through hydrogen-bonding. The incorporation into liposomes maintained the antibacterial effect of carvacrol, but when in the film, carvacrol liposomes were not effective against the microorganisms tested. Liposomes may offer a viable option for stabilizing carvacrol, however, more studies are necessary to enable its application in food packaging.