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SARS-CoV-2 spike proteins react with Au and Si, are electrically conductive and denature at 3 × 10<sup>8</sup> V m<sup>−1</sup>: a surface bonding and a single-protein circuit study

Essam M. Dief, Nadim Darwish

2023Chemical Science17 citationsDOIOpen Access PDF

Abstract

, the conducting channels are blocked and this is attributed to the spike protein denaturing in the nano-gap. These findings open new venues for developing coronavirus-capturing materials and offer an electrical method for analysing, detecting and potentially electrically deactivating coronaviruses and their future variants.

Topics & Concepts

Quantum tunnellingMoleculeElectrical conductorBreak junctionChemistryMaterials scienceCrystallographyNanotechnologyOptoelectronicsComposite materialOrganic chemistryMolecular Junctions and NanostructuresAdvanced biosensing and bioanalysis techniquesElectrochemical Analysis and Applications
SARS-CoV-2 spike proteins react with Au and Si, are electrically conductive and denature at 3 × 10<sup>8</sup> V m<sup>−1</sup>: a surface bonding and a single-protein circuit study | Litcius