Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model
Anne Meyer-Miner, Jenica L.M. Van Gennip, Katrin Henke, Matthew P. Harris, Brian Ciruna
Abstract
mutants as a new IS model. We define essential roles for Katnb1 in motile ciliated lineages, uncouple EC cilia and RF formation defects from spinal curvature, and identify abnormal CSF flow and cell stress responses as shared pathogenic signatures associated with scoliosis across diverse zebrafish models.
Topics & Concepts
ZebrafishCiliumNeuroscienceCell biologyBiologyNeuroinflammationScoliosisCerebrospinal fluidMotile ciliumMotilityAnatomyPathologyInflammationMedicineImmunologyGeneticsGeneConnective tissue disorders researchKruppel-like factors researchMoyamoya disease diagnosis and treatment