Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation
Wei Sun, Qingpeng Wang, Ruiyan Zhang, Ning Zhang
Abstract
in the KD + EAE group. Further studies demonstrated that KD suppresses inflammatory response and M1 microglial polarization by inhibiting the TLR4/MyD88/NF-κB/NLRP3 pathway, the JAK1/STAT1 pathway, HDAC3 and P2X7R activation, as well as up-regulation of JAK3/STAT6.
Topics & Concepts
MicrogliaNeuroinflammationExperimental autoimmune encephalomyelitisNeuroprotectionCCR2CCL2Proinflammatory cytokineMultiple sclerosisImmunologyNeurodegenerationChemokineTLR4MedicineInflammationChemistryPharmacologyInternal medicineChemokine receptorDiseaseDietary Effects on HealthTryptophan and brain disordersImmune Cell Function and Interaction