Anisotanols A—D, Four Norsesquiterpenoids with an Unprecedented Sesquiterpenoid Skeleton from <i>Anisodus tanguticus</i><sup>‡</sup>
Haoyu Zhao, Qin‐Mei Zhou, Huan Zhu, Fei Zhou, Chun‐Wang Meng, Hong‐Zhen Shu, Zhaohua Liu, Cheng Peng, Liang Xiong
Abstract
Main observation and conclusion Anisotanols A—D (1—4), four new compounds possessing an unprecedented sesquiterpenoid skeleton with a congested tricyclic 6/3/5 ring system, were obtained from Anisodus tanguticus . Their structures were elucidated by comprehensive spectroscopic techniques, and the absolute configurations were confirmed via ECD calculations and single‐crystal X‐ray diffractions. A putative biosynthetic pathway for these compounds was proposed. Biological evaluation disclosed that compound 3 showed anti‐angiogenic activity by inhibiting the viability, migration, and tube formation in HUVECs.
Topics & Concepts
ChemistrySkeleton (computer programming)StereochemistryRing (chemistry)TricyclicAbsolute configurationTerpeneOrganic chemistryAnatomyMedicineSesquiterpenes and Asteraceae StudiesMarine Sponges and Natural ProductsBioactive Natural Diterpenoids Research