Genetic Code Expansion: Inception, Development, Commercialization
Miglena Manandhar, Eugene Chun, Floyd E. Romesberg
Abstract
, we review the history and current state of the field. We also provide a review of the first generation commercialization efforts, the lessons learned, and how those lessons are guiding new efforts. With continued academic and industrial progress, GCE methodologies promise to make possible the routine optimization of proteins for therapeutic use in a way that has only previously been possible with small-molecule therapeutics.
Topics & Concepts
CommercializationGenetic codeComputational biologyENCODEField (mathematics)Amino acidChemistryCode (set theory)Computer scienceGeneBiologyBiochemistryProgramming languageBusinessSet (abstract data type)MathematicsMarketingPure mathematicsRNA and protein synthesis mechanismsBacterial Genetics and BiotechnologyMonoclonal and Polyclonal Antibodies Research