Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma
Karin Hansson, Katarzyna Radke, Kristina Aaltonen, Jani Saarela, Adriana Mañas, Jonas Sjölund, Emma Smith, Kristian Pietras, Sven Påhlman, Krister Wennerberg, David Gisselsson, Daniel Bexell
Abstract
-amplified neuroblastoma PDX tumors. Furthermore, treatment of mice harboring orthotopic neuroblastoma PDX tumors resulted in increased survival. Our results suggested that KSP inhibition could be a promising treatment strategy in children with high-risk neuroblastoma.
Topics & Concepts
NeuroblastomaCancer researchProgrammed cell deathMitosisMedicineOncologyBiologyApoptosisCell biologyCell cultureGeneticsNeuroblastoma Research and TreatmentsCancer, Hypoxia, and MetabolismCancer therapeutics and mechanisms