Increased CFTR expression and function from an optimized lentiviral vector for cystic fibrosis gene therapy
Laura Marquez‐Loza, Ashley L. Cooney, Qian Dong, Christoph O. Randak, Stefano Rivella, Patrick L. Sinn, Paul B. McCray
Abstract
sequences advance lentiviral vectors toward CF gene therapy clinical trials.
Topics & Concepts
Cystic fibrosisGenetic enhancementViral vectorVector (molecular biology)Function (biology)Gene expressionCystic fibrosis transmembrane conductance regulatorComputational biologyBiologyGeneVirologyMedicineCancer researchGeneticsRecombinant DNAVirus-based gene therapy researchEnergy Harvesting in Wireless NetworksCystic Fibrosis Research Advances