Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis
Chih‐Jie Shen, Kwang‐Yu Chang, Bo-Wen Lin, Wei‐Ting Lin, C Su, Jhih-Peng Tsai, Yu-Han Liao, Liang‐Yi Hung, Wen‐Chang Chang, Ben‐Kuen Chen
Abstract
The coincident expression of NOX4 and ANGPTL4 in CRC tumor specimens provides the insight into the potential therapeutic targets for the treatment of dyslipidemia-associated CRC metastasis.
Topics & Concepts
Colorectal cancerMetastasisOleic acidANGPTL4CancerCancer researchNOX4Mouse model of colorectal and intestinal cancerInternal medicineMedicineBiologyOncologyDownregulation and upregulationGeneBiochemistryLipid metabolism and disordersCancer, Lipids, and MetabolismCancer-related molecular mechanisms research