Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability
Saleh Ihmaid, Shaya Y. Al‐Raqa, Mohamed Reda Aouad, Ateyatallah Aljuhani, Hossein M. Elbadawy, Samir A. Salama, Nadjet Rezki, Hany E. A. Ahmed
Topics & Concepts
ChemistryPhthalimideCytotoxicityLinkerEGFR inhibitorsMTT assayDocking (animal)StereochemistryIC50TriazoleMolecular modelCombinatorial chemistryIn vitroBiochemistryEpidermal growth factor receptorReceptorOrganic chemistryMedicineComputer scienceNursingOperating systemClick Chemistry and ApplicationsCancer therapeutics and mechanismsProtein Degradation and Inhibitors