Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
Randi Bonke Mikkelsen, Tulika Arora, Kajetan Trôst, Oksana Dmytriyeva, Sune K. Yang-Jensen, Abraham S. Meijnikman, Louise E. Olofsson, Dimitra Lappa, Ömrüm Aydin, Jens Nielsen, Victor E. A. Gerdes, Thomas Moritz, Arnold van de Laar, Maurits de Brauw, Max Nieuwdorp, Siv A. Hjorth, Thue W. Schwartz, Fredrik Bäckhed
Abstract
. Our findings indicate that 3-hydroxydecanoate is a T2D-associated metabolite that increases inflammatory responses and may contribute to the chronic inflammation observed in diabetes.
Topics & Concepts
InflammationType 2 diabetesAdipose tissueDiabetes mellitusImmune systemReceptorMetabolitePharmacologyEndocrinologyInternal medicineImmunologyBiologyMedicineAdipokines, Inflammation, and Metabolic DiseasesDiabetes Treatment and ManagementImmune Cell Function and Interaction