Dithiolation of Alkenyl Sulfonium Salts with Arylthiols to Access 1,2-Dithioalkanes
Jie Zhu, Jinghui Sun, Yifei Yan, Zhuyong Dong, Yinhua Huang
Abstract
A dithiolation of alkenyl sulfonium salts with arylthiols is described, affording a series of 1,2-dithioalkanes in high yields. This protocol features mild and catalyst-free conditions and involves the formation of two C-S bonds sequentially via the regioselective addition of an arylthiol to the unsaturated C═C bonds, followed by the attack of another arylthiol to form 1,2-dithioalkanes exclusively.
Topics & Concepts
SulfoniumRegioselectivityChemistryCatalysisMedicinal chemistryPolymer chemistryOrganic chemistrySalt (chemistry)Sulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions