Epigenetic Drugs and Their Immune Modulating Potential in Cancers
Yingying Liang, Şevin Turcan
Abstract
Epigenetic drugs are used for the clinical treatment of hematologic malignancies; however, their therapeutic potential in solid tumors is still under investigation. Current evidence suggests that epigenetic drugs may lead to antitumor immunity by increasing antigen presentation and may enhance the therapeutic effect of immune checkpoint inhibitors. Here, we highlight their impact on the tumor epigenome and discuss the recent evidence that epigenetic agents may optimize the immune microenvironment and promote antiviral response.
Topics & Concepts
EpigenomeEpigeneticsImmune systemEpigenetic therapyImmune checkpointImmunologyImmunityBiologyCancer researchImmunotherapyTumor microenvironmentMedicineBioinformaticsDNA methylationGeneticsGene expressionGeneEpigenetics and DNA MethylationHistone Deacetylase Inhibitors ResearchImmune cells in cancer