Copper-catalyzed carbonylative multi-component borylamidation of alkenes for synthesizing γ-boryl amides with CO as both methylene and carbonyl sources
Hui‐Qing Geng, Yan-Hua Zhao, Peng Yang, Xiao‐Feng Wu
Abstract
, and CO with good yields and excellent diastereomeric ratios. Notably, two CO molecules were converted to methylene and carbonyl groups in the target amides. A series of amines were successfully involved in the transformation, including arylamines, aliphatic amines, and hydrochloride salts of secondary aliphatic amines.
Topics & Concepts
CatalysisComponent (thermodynamics)MethyleneCopperChemistryOrganic chemistryMedicinal chemistryCombinatorial chemistryPhysicsThermodynamicsOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods