Evolutionary Divergence in DNA Damage Responses among Fungi
Jacob L. Steenwyk
Abstract
Cell cycle checkpoints and DNA repair pathways contribute to maintaining genome integrity and are thought to be evolutionarily ancient and broadly conserved. For example, in the yeast Saccharomyces cerevisiae and humans, DNA damage induces activation of a checkpoint effector kinase, Rad53p (human homolog Chk2), to promote cell cycle arrest and transcription of DNA repair genes.
Topics & Concepts
DNA damageG2-M DNA damage checkpointSaccharomyces cerevisiaeDNA repairEffectorCheckpoint Kinase 2BiologyDNACell cycle checkpointCHEK1Cell biologyDNA re-replicationGeneGenome instabilityGeneticsGenomeCell cycleEukaryotic DNA replicationDNA Repair MechanismsFungal and yeast genetics researchCRISPR and Genetic Engineering